METABOLIC ROUTE COMPUTATION IN ORGANISM COMMUNITIES

Metabolic route computation in organism communities

Abstract Background Microbiomes are complex aggregates of organisms, each of which has its own extensive metabolic network.A variety Conditioning Masque of metabolites are exchanged between the microbes.The challenge we address is understanding the overall metabolic capabilities of a microbiome: through what series of metabolic transformations can

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Lottery Rank-Pruning Adaptation Parameter Efficient Fine-Tuning

Recent studies on parameter-efficient fine-tuning (PEFT) have introduced effective and efficient methods for fine-tuning large language models (LLMs) on downstream tasks using fewer parameters than required by full fine-tuning.Low-rank decomposition adaptation (LoRA) significantly reduces the parameter count to 0.03% of that in full fine-tuning, ma

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Pinus densiflora extract protects human skin fibroblasts against UVB-induced photoaging by inhibiting the expression of MMPs and increasing type I procollagen expression

Exposure to ultraviolet (UV) light can cause skin photoaging, which is associated with upregulation of matrix metalloproteinases Meat Slicers (MMPs) and downregulation of collagen synthesis.It has been reported that MMPs, especially MMP-1, MMP-3 and MMP-9, decrease the elasticity of the dermis by degrading collagen.In this study, we assessed the ef

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